Injury Watch: Key Players Sidelined & What It Means for Week 4

Injuries are one of those wildcards that can instantly flip a betting line, derail a team’s game plan, or elevate a lesser-known player into the spotlight. As we head into Week 4 of the 2025 NFL season, several major injury updates are worth watching — not just for fantasy, but for bettors, analysts, and fans alike.

🔍 Major Injuries & Status Updates

  • Mike Evans, WR, Buccaneers: Hamstring injury, expected to miss multiple weeks. [Source]
  • CeeDee Lamb, WR, Cowboys: High-ankle sprain, could miss 3–4 weeks. [Source]
  • Tyler Booker, G, Cowboys: High-ankle sprain, expected out 4–6 weeks.
  • Cody Mauch, G, Buccaneers: Knee injury, moved to IR. [Source]
  • Nick Bosa, DE, 49ers: Knee issue, will miss at least one game.
  • James Conner, RB, Cardinals: Placed on IR with a foot injury.

🎯 Impact on Teams & Betting

These injuries shift offensive strategies, weaken pass protection, and impact how betting lines are set. Tampa Bay loses its deep threat in Evans, Dallas must adapt without Lamb, and Arizona will look to backups after Conner’s IR designation. Bettors should expect line movement and potential total adjustments.

✅ Betting Takeaways

  • Check final injury reports before betting.
  • Adjust prop bets (WR/RB unders, TE overs).
  • Expect lower totals in games with missing stars.
  • Be cautious of backup overhype.

Injuries are the X factor every week. The sharp bettors are the ones who adapt fastest.